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USP6 activates Neoplasm Invasiveness. 7 / 7
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"USP6 overexpression in colon cancer cell lines enhanced the invasion and aggregation of cancer cells in vitro and increased liver metastasis in vivo[72]."
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"According to a recent study, USP6 also contributes to resistance to hormone treatment and chemotherapy by improving the invasion and migratory capacities of breast cancer."
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"Furthermore, we demonstrate that inhibition of CD147 by a specific inhibitor alleviated the TRE17-promoted tumor cell invasion."
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"However, the role of USP6 in the development of colon cancer has not been explored previously.Hence, in the present study, we discovered that 1) USP6 was highly expressed the in tumor tissues than tho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the present study, we demonstrated that high USP6 expression could promote the invasion of colon cancer cells in vitro and liver metastasis in nude mice."
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"Suppression of USP6 expression inhibited the ability of colon cancer cells invasion and metastasis."
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"Ubiquitin-specific protease TRE17/USP6 promotes tumor cell invasion through the regulation of glycoprotein CD147 intracellular trafficking."
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