IndraLab

Statements

USP12 activates apoptotic process. 9 / 9
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"In fact, overexpression of WDR48 and USP12 induced apoptosis similarly to PHLPP1."
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"As a result, depleting Usp12 decreased PC cellular proliferation and increased cellular apoptosis suggesting it may be a potential target for CRPC therapy [XREF_BIBR]."
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"In this study, we identified significant upregulation of the m 6 A methyltransferase METTL3 (methyltransferase-like 3), the m 6 A reader protein YTHDF1 (YTH N6-methyladenosine RNA binding protein 1), as well as increased expression levels of USP12 (ubiquitin-specific peptidase 12), FOXO3 (forkhead box O3), and key molecules in the intrinsic apoptotic pathway, PUMA (p53 upregulated modulator of apoptosis) and BAX (Bcl-2-associated X), through proteomic profiling in an LPS (Lipopolysaccharide)-induced SIMD mouse model."
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"It has been mentioned previously that USP12 silencing inhibits PC cell proliferation, induces cell cycle arrest, and promotes apoptosis [42]."
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"Thus, these results suggest that WDR48 and USP12 negatively regulate Akt signaling and thereby induce apoptosis in conjunction with PHLPP1."
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"Invivo experiments showed that USP12-knockdown could suppress tumor growth in mice, and immuno blotting revealed that USP12 could induce G2/M arrest through the cyclin dependent kinase1 and cyclinB1 axis, and trigger apoptosis via the p38 and mitogen activated protein kinase pathway."
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"In vivo experiments showed that USP12-knockdown could suppress tumor growth in mice , and immuno-blotting revealed that USP12 could induce G2 / M arrest through the cyclin dependent kinase 1 / cyclinB1 axis , and trigger apoptosis via the p38 / mitogen-activated protein kinase pathway ."
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"Over-expression of USP12 induced apoptosis and suppressed the proliferation of HCT116 cells ( Gangula and Maddika, 2013 )."
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"WDR48 and USP12 Negatively Regulate Akt Signaling and Promote Apoptosis."
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