IndraLab

Statements

USP12 activates apoptotic process. 6 / 6
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"WDR48 and USP12 Negatively Regulate Akt Signaling and Promote Apoptosis."
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"In fact, overexpression of WDR48 and USP12 induced apoptosis similarly to PHLPP1."
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"Thus, these results suggest that WDR48 and USP12 negatively regulate Akt signaling and thereby induce apoptosis in conjunction with PHLPP1."
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"As a result, depleting Usp12 decreased PC cellular proliferation and increased cellular apoptosis suggesting it may be a potential target for CRPC therapy [XREF_BIBR]."
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"In vivo experiments showed that USP12-knockdown could suppress tumor growth in mice , and immuno-blotting revealed that USP12 could induce G2 / M arrest through the cyclin dependent kinase 1 / cyclinB1 axis , and trigger apoptosis via the p38 / mitogen-activated protein kinase pathway ."
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"Invivo experiments showed that USP12-knockdown could suppress tumor growth in mice, and immuno blotting revealed that USP12 could induce G2/M arrest through the cyclin dependent kinase1 and cyclinB1 axis, and trigger apoptosis via the p38 and mitogen activated protein kinase pathway."
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