IndraLab

Statements

USP14 inhibits CDKN1A. 3 / 3
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"Human USP14 shares high structural homology and conservation with yeast Ubp6 [ 51 ]; hence, we speculated that USP14 might be involved in PSMD2-mediated p21 and p27 degradation."
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"Interestingly, ectopic expression of USP14 decreased p21 abundance."
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"Similarly, knockdown of UCH37 and USP14 or b-AP15 treatment rescued p53 protein, induced by COPS5 overexpression, and enhanced the activity of transfected luciferase reporter plasmids for p53, Bax, and p21 expression and protein levels of p53 downstream target genes BAX and p21."
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