IndraLab

Statements

Clenbuterol inhibits KCNH2. 5 / 5
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"Clenbuterol Attenuates hERG Channel by Promoting the Mature Channel Degradation."
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"We found that clenbuterol decreases the mature form of the hERG protein at the cell membrane in a concentration- and time dependent manner, without affecting the immature form."
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"Correspondingly, clenbuterol chronic treatment reduced hERG current to a greater extent compared to acute treatment."
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"In the presence of Brefeldin A (BFA), which was used to block hERG channel trafficking to cell membrane, clenbuterol reduced hERG on plasma membrane to a greater extent than BFA alone."
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"In addition, the hERG channel 's drug binding sites mutant Y652A and F656A abolished clenbuterol mediated hERG reduction and current blockade."
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