IndraLab

Statements

Clenbuterol inhibits KCNH2. 5 / 5
| 5
reach
"We found that clenbuterol decreases the mature form of the hERG protein at the cell membrane in a concentration- and time dependent manner, without affecting the immature form."
28535735
reach
"In addition, the hERG channel 's drug binding sites mutant Y652A and F656A abolished clenbuterol mediated hERG reduction and current blockade."
28535735
reach
"In the presence of Brefeldin A (BFA), which was used to block hERG channel trafficking to cell membrane, clenbuterol reduced hERG on plasma membrane to a greater extent than BFA alone."
28535735
reach
"Correspondingly, clenbuterol chronic treatment reduced hERG current to a greater extent compared to acute treatment."
28535735
reach
"Clenbuterol Attenuates hERG Channel by Promoting the Mature Channel Degradation."
28535735