IndraLab

Statements

Diazoxide inhibits NLRP3. 3 / 3
| 3
reach
"In addition, diazoxide could also suppress the upregulation of NLRP3, ASC, and cleaved caspase 1induced by OGD/R in primary microglia and BV2 cells (all p < 0.01)."
30153825
reach
"Then we detected the activation of NLRP3 inflammsome pathway in rats during cerebral I/R injury, and found that the diazoxide could inhibit the activation of NLRP3 inflammasome, which indicated that mitochondrial dysfunction played a great role in activating NLRP3 inflammasome in cerebral I/R injury."
30153825
reach
"We further demonstrated that the mitochondrial protector diazoxide was able to reduce NLRP3 upregulation in a post-operative treatment paradigm."
33328988