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ERK activates SCN10A. 6 / 6
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"In support of this, it has also been reported that PKA [40, 62] and ERK [63, 64] modulate the Nav1.8 currents in small-diameter DRG neurons (Fig. 6)."
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"The activation of CXCL12-CXCR4 signaling induces an ERK-dependent up-regulation of Nav1.8, thus maintaining DRG neuronal hyperexcitability and persistent pancreatic pain hypersensitivity under CP."
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"Furthermore, we demonstrated that the BV-induced ERK activation and Nav1.8 up-regulation in the DRG could be blocked by pre-antagonism against CXCR4 in the periphery with AMD3100 as well as by blockade of ERK activation by intrathecal (i.t."
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"In summary, our present data demonstrated that, under the peripheral inflammatory pain condition, SDF1–CXCR4 signaling between non-neuronal SGCs and primary nociceptor neurons is dramatically enlarged through up-regulation of both substances in the DRG which acts as a mediator for the intraganglionar neuroinflammatory microenvironment and induces ERK-dependent up-regulation of Nav1.8 that contributes to the maintaining process of primary nociceptor neuronal hyperexcitability that is required for maintenance of persistent spontaneous pain and hypersensitivity."
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"The phosphorylation of ERK has been shown to be critical for up-regulation of Nav1.8 [56]."
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"Phosphorylation of Nrf2 in HepG2 cells was enhanced in PN3, which was mediated by PKCdelta, ERK, and p38 MAPK."
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