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Short hairpin RNA inhibits USP14. 1 / 1
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"We found that USP14 inhibition by shRNA significantly suppressed the proliferation of MDA-MB-231, MDA-MB-453, MDA-MB-468, HCC1937, and MCF7 breast cancer cell lines (Fig. xref a– xref ); however USP14 knockdown did not affect the proliferation of T47D cells (Fig. xref ), which could be related to the fact that these cells express very high levels of ER and very low levels of AR (Fig. xref )."