IndraLab

Statements

Hh3 binds SCN5A. 8 / 8
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"The initial classification results derived from conventional ML classifiers and InSAR features set by PCA analysis are shown in xref , in which classification maps of HH1–HH3 packets and a hybrid packet are illustrated."
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"3243A > G heteroplasmy (HH1–HH3) showed spontaneous activity with bursts ( Figures 5 D–5F) of a relatively similar duration ( Figure S4 C) and comparable number of spikes as iNeurons with LH ( Figure [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, the amount and pattern of spike and network bursting in HH1–HH3 networks were significantly different compared with their respective LH isogenic CTRs."
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"We found that the general level of activity (mean firing rate [MFR]) exhibited by the HH1–HH3 networks was strongly reduced ( Figure 5 G)."
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"Furthermore, HH1–HH3 networks presented with a reduced network burst rate (NBR) ( Figure 5 I), with HH1 and HH3 networks exhibiting virtually no network bursts ( Figures 5 D, 5F, and 5I)."
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"Finally, we also observed that spike organization in HH1–HH3 networks differed from CTRs, as indicated by the higher percentage of random spikes (PRS) occurring outside of the network bursts ( Figure [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The operating pressures applied were between 1.5 and 2.5 bar (BA1–BA6, BR1–BR2, LR1) during the disinfection operations (food industry, private hygiene), 7–40 bar (high-pressure cleaners) during the m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We treated MEA-grown neuronal networks (HH1–HH3) short term (2 weeks; DIV29–DIV44) and long-term (6 weeks; DIV3–DIV44), with different concentrations of sonlicromanol (0.5 μM, 1 μM, 3 μM, and 5μM + dimethyl sulfoxide [DMSO] vehicle condition), and recorded network activity at DIV30, DIV37, and DIV44 ( xref A)."
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