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USP12 deubiquitinates YAP1. 4 / 4
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"Further ubiquitination experiments demonstrated that only the USP12 could deubiquitinate YAP proteins, while the mutant USP12 , lacking deubiquitinating enzyme activity, could not (Fig. 7E, F)."
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"The results showed that the deubiquitination of YAP by USP12 was observed in both nucleus and cytoplasm (Supplementary Fig. S3A)."
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"Besides, USP12 interacted with YAP protein, suppressing YAP poly-ubiquitination by K48-linked and preventing proteasome-mediated degradation in gastric cancer cells."
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"To further elucidate the mechanism by which USP12 deubiquitinates YAP, we investigated the specific site on the YAP protein targeted by USP12."
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