IndraLab

Statements

USP2 activates CD274. 3 / 3
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"USP2 promotes tumor immune evasion via deubiquitination and stabilization of PD-L1."
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"USP2 directly interacts with and increases PD-L1 abundance in colorectal and prostate cancer cells."
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"These data demonstrate that CD8 + T cells, but not CD4 + T cells, are the primary effector cells underlying the combination treatment in these tumor models.Finally, to ascertain whether USP2 inhibition potentiates the efficacy of PD-1/PD-L1 blockade by enhancing p53 function in a tumor cell autonomous manner, we also examined the effects of combination therapy in Balb/c mice bearing p53-null EMT6 tumors."
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