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CYLD inhibits cell migration. 9 / 9
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"In addition, CYLD substantially slowed down scratchwounding induced cell migration (XREF_FIG)."
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"We found in Supplementary Figure 6A–C that CYLD over-expression suppressed cell proliferation and cell migration and invasion, whereas promoted apoptosis in SiHa cells."
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"Furthermore , we found that CYLD deficiency promoted cervical cancer cell proliferation , colony formation , cell migration and invasion , and inhibited apoptosis instead , whereas it is just opposite with CYLD over-expression ."
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"The in vitro chamber migration and wound healing assays show that CYLD dramatically suppresses cell migration in both HK1 and C17 (XREF_FIG D, E, Figure S3)."
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"In addition, CYLD m induced an increased rate of cell migration as assessed by a scratch wounding assay, while CYLD WT markedly slowed cell migration (XREF_FIG)."
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"The data are consistent with CYLD acting as a tumor suppressor gene to inhibit cell migration in vitro and metastasis in vivo."
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"XREF_BIBR Additionally, Sanches et al XREF_BIBR showed that CYLD suppresses cell migration and invasion in cervical cancer, and Suenaga et al XREF_BIBR reported that CYLD downregulates induction of cisplatin resistance in oral squamous cell carcinoma."
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"Moreover, the wound healing assay shows that CYLD WT inhibits cell migration, while S323X and S371X showed significant differences with the WT (XREF_FIG E)."
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"In addition, both wound healing assay (Fig. 5B) and transwell migration assay (Fig. 5C) showed that gefitinib treatment indeed suppressed cell migration caused by CYLD knockdown."
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