IndraLab

Statements

BAP1 increases the amount of CDKN1B. 5 / 5
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"Depletion of KLF5, BAP1 or HCF-1 also upregulated p27 mRNA levels (XREF_FIG)."
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"Knockdown of either KLF5 or BAP1 upregulated p27 protein levels in these breast cell lines as well (XREF_FIG; XREF_SUPPLEMENTARY)."
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"Indeed, depletion of KLF5, BAP1, HCF-1 or OGT upregulated p27 protein expression and blocked cell cycle progression (XREF_FIG)."
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"Given that depletion of BAP1 or KLF5 markedly increased p27 protein levels, we speculated that the protein complex might regulate the expression of p27 and FGF-BP (a KLF5 target gene)."
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"Knockdown of KLF5, BAP1 or HCF-1, but not OGT, significantly increased p27 mRNA levels (XREF_FIG)."
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