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USP4 deubiquitinates PRPF31. 7 / 8
1 | 7

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"For progression of the splicing cycle, ubiquitinated PRP3 and PRP31 get deubiquitinated by the ubiquitin-specific proteases USP4 and USP15, respectively [28,29] ( Figure 1 )."

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"When PRP31 was ubiquitinated by PRP19, PRP31 was deubiquitinated by USP4."

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"Moreover, we found that USP15 and USP4 deubiquitinated substrates PRP31 and PRP3 simultaneously."

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"Moreover, it was reported that Sart3, Usp4 and Usp15 form a complex in order to de-ubiquitinate Prp3 and Prp31 simultaneously."
| PMC

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"As the splicing cycle progresses, PRPF3 and PRPF31 are deubiquitinated by USP4 and USP15, respectively (Song et al., 2010; Das et al., 2017)."

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"Deubiquitination of PRP31 and PRP3 by the USP15, SART3, and USP4 complex decreases the affinity towards PRP8 and this regulation is important for the proper splicing of chromosome segregation related genes such as Bub1 and alpha-tubulin."

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"It is possible that localization of USP15 and USP4 may be regulated by phosphorylation or a nuclear signal such as NLS and NES depending on the cellular conditions.USP15 and USP4 are required for the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"