IndraLab

Statements

OTUD5 binds MYD88. 9 / 9
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"A previous study revealed that OTUD5 interacts with MyD88, therefore promoting TLR/IL-1R mediated signal transduction."
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"To further confirm the interaction of OTUD5 with MyD88, we obtained PMs from WT mice."
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"The coimmunoprecipitation (Co-IP) analysis revealed that OTUD5 interacts with MyD88 but not IRAK4, IRAK2, or TRAF6 (Fig.  xref )."
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"Taken together, these findings suggested that OTUD5 interacts with MyD88 but not the other adapter molecules involved in TLR/IL-1R signaling."
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"Mechanistically, OTUD5 interacted with MyD88 and cleaved its K11-Ub, which enhanced MyD88 oligomerization and subsequently promoted Myddosome formation, activation of NF-κB and MAPK signaling, and inflammatory cytokine production ( xref )."
40469292
sparser
"OTUD5 directly interacts with MyD88 and cleaves its K11-linked polyubiquitin chains at Lys95, Lys231 and Lys250."
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"OTUD5 can directly interact with MyD88 and removed its K11-linked polyubiquitination."
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"OTUD5 interacts with MyD88."
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"These collective findings indicated that OTUD5 interacts with MyD88 through the amino acids 360-571 on OTUD5 and the death domain of MyD88."
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