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Statements

UIM3 activates USP37. 2 / 2
| 1 1
eidos
"Furthermore , UIM2 and UIM3 selectively bind to the proximal ubiquitin of K48-linked chains to enhance cleavage by USP37 , whereas UIM1 is not involved in substrate recognition [ 94 ] ."
| PMC
reach
"Therefore, the difference in the ability of the UIMs to bind ubiquitin plays a differential role on the kinetic parameters of USP37 depending on the type of ubiquitin chain, shedding light on the mechanism of substrate selection by USP37.When individual UIM mutants were tested, the authors found that UIM2 and UIM3 modulate the ability of USP37 to cleave all ubiquitin chain types, in contrast with that of UIM1."
| PMC