IndraLab

Statements

USP8 deubiquitinates TARDBP. 3 / 3
| 3
reach
"Deficiency of UBPY noticeably promotes TDP-43 ubiquitination but the resulting conjugates may serve as unfavorable proteasomal substrates or just overburden the proteasome."
36158183
reach
"In D. melanogaster models, the ubiquitin conjugating enzyme UBE2E3 promotes ubiquitination of TDP-43; in contrast, ubiquitin isopeptidase Y (UBPY) decreased TDP-43 ubiquitination."
27693252
reach
"TDP-43 is deubiquitinated by UBPY, but not by the catalytically inactive UBPY."
34023421