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EGF activates USP8. 3 / 3
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"Collectively, these data demonstrate that the Cbl binding site of the wild-type EGFR and the EGFR-ErbB2 chimera is not required for efficient EGF induced Usp8 tyrosine phosphorylation or coprecipitati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"EGF treatment induced a faster degradation of EGFR protein in HeLa cells expressing WT USP8 compared to mutants, although EGFR protein levels were comparable in these cells under serum starved conditions (XREF_FIG)."

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"As we have demonstrated before, deletion of the MIT-domain in Usp8 results in decreased EGF induced Usp8 tyrosine phosphorylation [17]."