IndraLab

Statements

BRCC3 decreases the amount of CTNNB1. 4 / 4
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"Recent studies by our research group have demonstrated that BRCC36 can inhibit the osteogenic differentiation of VSMCs by affecting the phosphorylation level of β-catenin in vitro [23]."
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"BRCC36 overexpression reduced the phosphorylation level of β-catenin at S675, a known site that augments β-catenin transcriptional activity (Fig. 5J)."
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"BRCC36 overexpression also reduced Wnt activity, as determined by TopFlash/FopFlash analysis, and downregulated the expression of classic β-catenin target genes (cyclin D1 and c-myc)."
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"Depletion of BRCC36 can promote the activation of alkaline phosphatase, formation of calcified nodules and the increase of β-catenin protein level in osteoblasts isolated from patients with osteoporos[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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