IndraLab

Statements

BRCC3 decreases the amount of ZEB1. 4 / 4
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"The immunohistochemistry results showed that BRCC3 interference upregulated E-cadherin expression and downregulated ZEB1 and vimentin expressions, and ZEB1 abolished these effects ( Figure 6D‒F)."
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"BRCC3 interacts with ZEB1 and interferes with BRCC3 to inhibit ZEB1 expression by increasing ZEB1 ubiquitination."
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"Western blot analysis showed that interference with BRCC3 upregulated E-cadherin protein expression and downregulated BRCC3, ZEB1 and vimentin protein expressions, and overexpression of ZEB1 reversed these effects ( Figure 4F)."
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"Interference with BRCC3 promotes ZEB1 protein degradation and inhibits ZEB1 expression by increasing its ubiquitination level."
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