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USP7 activates Neoplasm Invasiveness. 48 / 48
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"According to our detection, knockdown of USP7 could decrease the invasion of OVCAR3 cells by 25%, and overexpression of USP7 could remarkably increase the invasion of SKOV3 cells by ~ 50%, suggesting the critical role of USP7 in EOC invasion (XREF_FIG)."
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"The knockdown of USP7 significantly inhibited cell invasiveness."
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"USP7, another predicted TF in this study, was reported to promote proliferation, migration and invasion of HB cell lines through activation of PI3K/AKT signaling (Ye et al., 2021)."
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"8 , 12 Our group has also demonstrated that USP7 inhibition suppresses melanoma cell proliferation, migration, and invasion."
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"Cellular studies showed that USP7 could enhance the proliferation, migration, and invasion capacities of HCC cells, thereby promoting tumor progression."
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"USP7 silencing decreased proliferation, migration, and invasion rates of HCC cells."
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"Subsequently, using SKOV3 human ovarian adenocarcinoma cells, we showed that either USP7 or MARCH7 enhanced the proliferation and invasion abilities."
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"USP7 silencing suppresses CC cell proliferation, migration, invasion, angiogenesis and macrophage M2 polarization."
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"USP7 promoted cell proliferation, migration, invasion in vitro and tumor growth by stabilizing TAZ."
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"Further experiments showed that down-regulation of USP7 could reduce cell proliferation , migration , and invasion ."
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"Furthermore, our cellular experiments showed that USP7 can directly enhance the proliferation and invasion of HCC cells, demonstrating its potential as a drug target."
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"Wound healing and transwell assays revealed that knockdown of USP7 or YY1 inhibited cell migration and invasion, and double knockdown enhanced this suppression effect in HCT116 (Fig. 6A–C), LOVO (Fig. 6D–F), and DLD1 cells (Fig. 6G–I)."
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"Similarly, overexpression USP7 enhanced the invasion ability of HCC cells as showed by the Matrigel-Transwell assay, while USP7-knockdown attenuated the invasion process (XREF_FIG)."
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"The silencing of USP7 could impair CC cell proliferation, migration, invasion, and angiogenesis, as well as suppress macrophage M2 polarization."
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"Accordingly, we conducted cellular experiments using 2 human HCC cell lines; both showed that high expression of USP7 can promote tumor cell proliferation and invasion."
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"Functionally, USP7 overexpression promoted cell growth and invasion via deubiquitination of EZH2."
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"Herein, functional assays showed that the inhibition of USP7 decreased cell proliferation migration and invasion abilities but increased apoptosis in ERPBC."
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"The RNA inteference and overexpression assays indicated that USP7 can positively regulate the ovarian cell vitality and invasion process."
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"USP7 is able to enhance cancer cell invasiveness and proliferation by stabilizing EZH2, depending on its deubiquitination."
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"Suppression of OSCC cell migration and invasion by USP7 knockdown The migration and invasion abilities were examined to investigate how USP7 may influence OSCC cells malignancy ."
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"Over-expression of USP7 promotes cell invasiveness, whereas USP7 knock-down inhibits cell viability in ovarian cancer cells (Ma and Yu, 2016; Tavana and Gu, 2017)."
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"USP7 could promote the viability and invasion of OC cells."
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"For example, increased USP7 expression in oral squamous cell carcinoma promotes tumor cell proliferation and invasion [31]."
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"Additionally, Liang et al. revealed that Usp7 regulates human terminal erythroid differentiation [22] and promotes the invasion and metastasis of cancer [25]."
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"USP7 promotes malignancy of OSCC cells via activating Akt / ERK signaling pathway The present data showed that USP7 could promote OSCC cell migration and invasion ."
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"These data suggested that USP7 increased cell migration and invasion abilities by inducing EMT of OSCC cells ."
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"USP7 promoted migration, invasion, and EMT of HCC cells."
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"In OSCC cells , USP7 was shown to promote cell proliferation , inhibit apoptosis , enhance cell migration and invasion , and activate the Akt / ERK pathway ."
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"The present data showed that USP7 could promote OSCC cell migration and invasion."
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"These data suggested that USP7 increased cell migration and invasion abilities by inducing EMT of OSCC cells."
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"These results indicated that USP7 potentially participates in EMT to promote NSCLC cell invasiveness."
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"In OSCC cells, USP7 was shown to promote cell proliferation, inhibit apoptosis, enhance cell migration and invasion, and activate the Akt/ERK pathway."
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"USP7 promoted cell proliferation , migration , invasion in vitro and tumor growth by stabilizing TAZ ."
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"Of interest, it has also been suggested that inhibition of USP7 inhibits the migration and invasion of cancer cells [36]."
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"Transwell and wound-healing experiments showed that USP7 knockdown inhibited the invasion (Fig. 4D and E) and migration (Fig. 4F and G) activity of HCC cells, and USP7 overexpression promoted the invasion and migration ability of HCC cells."
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"Suppression of OSCC cell migration and invasion by USP7 knockdown."
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"Transwell assays showed that USP7 knockdown obviously suppressed OSCC cells migration and invasion compared to control groups (Figure 3B-C)."
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"Next, biological function assays demonstrated that USP7 knockdown markedly inhibited OS cell migration and invasion, whereas USP7 overexpression enhanced it."
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"Subsequently, USP7 promoted GBM proliferation and invasion by stabilizing the KPNB1-YBX1-NLGN3 signaling axis in vitro and in vivo."
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"In vitro studies also showed that downregulation of USP7 reduced proliferation of MHCC97-H cell lines and upregulation increased proliferation of Huh7 and Hep3B cell lines, suggesting that USP7 promoted HCC progression.31 Wang et al.70 performed wound healing assay and cell invasion assay to show that overexpression of USP7 can enhance invasion of HCC cells, while USP7-knockdown can suppress HCC invasion."
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"CARM1 and USP7 dependent LSD1 stabilization promotes invasion and metastasis of breast cancer cells [XREF_BIBR]."
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"USP7 promotes cell migration , invasion , and sphere formation in part through EZH2 stabilization In prostate cancer , USP7 overexpression has been reported to show a direct correlation with tumor aggressiveness ( Song et al ., 2008 ) ."
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"Similarly, USP7 overexpression in patients with epithelial ovarian cancer was found to induce cell invasion and correlate with poor survival."
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"As depicted in Fig. 6A, C, knockdown of Pol ι and USP7 inhibited the migration, invasion, and motility of ECA-109 cells under low-oxygen conditions, while cells overexpressing Pol ι/USP7 showed significantly increased migration and invasion abilities compared to the control (Fig. 6B, D)."
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"We found that USP7 knockdown significantly inhibited cell invasiveness."
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"To assess the metastasis potential of these three groups of RMS cells, various studies were performed, showing that decreased USP7 expression in RD and A204 cells significantly inhibited RMS cell invasion and metastasis."
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"USP7 has been shown to induce prostate cancer cell migration and invasion by stabilizing the Enhancer of Zeste homolog 2 (EZH2) gene."
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"Furthermore, the USP7 specific inhibitor P5091 augmented the inhibition of cell migration, invasion, and sphere forming abilities by EZH2 inhibitors in prostate cancer cells."
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