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USP7 activates Neoplasm Invasiveness. 34 / 34
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"Subsequently, using SKOV3 human ovarian adenocarcinoma cells, we showed that either USP7 or MARCH7 enhanced the proliferation and invasion abilities."
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"Functionally, USP7 overexpression promoted cell growth and invasion via deubiquitination of EZH2."
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"We found that USP7 knockdown significantly inhibited cell invasiveness."
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"In OSCC cells, USP7 was shown to promote cell proliferation, inhibit apoptosis, enhance cell migration and invasion, and activate the Akt/ERK pathway."
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"USP7 silencing decreased proliferation, migration, and invasion rates of HCC cells."
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"Similarly, USP7 overexpression in patients with epithelial ovarian cancer was found to induce cell invasion and correlate with poor survival."
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"These data suggested that USP7 increased cell migration and invasion abilities by inducing EMT of OSCC cells."
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"CARM1 and USP7 dependent LSD1 stabilization promotes invasion and metastasis of breast cancer cells [XREF_BIBR]."
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"Over-expression of USP7 promotes cell invasiveness, whereas USP7 knock-down inhibits cell viability in ovarian cancer cells (Ma and Yu, 2016; Tavana and Gu, 2017)."
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"USP7, another predicted TF in this study, was reported to promote proliferation, migration and invasion of HB cell lines through activation of PI3K/AKT signaling (Ye et al., 2021)."
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"Furthermore, the USP7 specific inhibitor P5091 augmented the inhibition of cell migration, invasion, and sphere forming abilities by EZH2 inhibitors in prostate cancer cells."
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"In OSCC cells , USP7 was shown to promote cell proliferation , inhibit apoptosis , enhance cell migration and invasion , and activate the Akt / ERK pathway ."
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"USP7 promoted cell proliferation , migration , invasion in vitro and tumor growth by stabilizing TAZ ."
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"Suppression of OSCC cell migration and invasion by USP7 knockdown The migration and invasion abilities were examined to investigate how USP7 may influence OSCC cells malignancy ."
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"Furthermore, our cellular experiments showed that USP7 can directly enhance the proliferation and invasion of HCC cells, demonstrating its potential as a drug target."
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"USP7 could promote the viability and invasion of OC cells."
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"These results indicated that USP7 potentially participates in EMT to promote NSCLC cell invasiveness."
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"Suppression of OSCC cell migration and invasion by USP7 knockdown."
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"USP7 promoted cell proliferation, migration, invasion in vitro and tumor growth by stabilizing TAZ."
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"These data suggested that USP7 increased cell migration and invasion abilities by inducing EMT of OSCC cells ."
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"Of interest, it has also been suggested that inhibition of USP7 inhibits the migration and invasion of cancer cells [36]."
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"Cellular studies showed that USP7 could enhance the proliferation, migration, and invasion capacities of HCC cells, thereby promoting tumor progression."
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"USP7 promotes malignancy of OSCC cells via activating Akt / ERK signaling pathway The present data showed that USP7 could promote OSCC cell migration and invasion ."
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"Similarly, overexpression USP7 enhanced the invasion ability of HCC cells as showed by the Matrigel-Transwell assay, while USP7-knockdown attenuated the invasion process (XREF_FIG)."
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"The present data showed that USP7 could promote OSCC cell migration and invasion."
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"Further experiments showed that down-regulation of USP7 could reduce cell proliferation , migration , and invasion ."
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"The RNA inteference and overexpression assays indicated that USP7 can positively regulate the ovarian cell vitality and invasion process."
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"Transwell assays showed that USP7 knockdown obviously suppressed OSCC cells migration and invasion compared to control groups (Figure 3B-C)."
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"According to our detection, knockdown of USP7 could decrease the invasion of OVCAR3 cells by 25%, and overexpression of USP7 could remarkably increase the invasion of SKOV3 cells by ~ 50%, suggesting the critical role of USP7 in EOC invasion (XREF_FIG)."
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"The knockdown of USP7 significantly inhibited cell invasiveness."
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"USP7 promotes cell migration , invasion , and sphere formation in part through EZH2 stabilization In prostate cancer , USP7 overexpression has been reported to show a direct correlation with tumor aggressiveness ( Song et al ., 2008 ) ."
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"Additionally, Liang et al. revealed that Usp7 regulates human terminal erythroid differentiation [22] and promotes the invasion and metastasis of cancer [25]."
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"Accordingly, we conducted cellular experiments using 2 human HCC cell lines; both showed that high expression of USP7 can promote tumor cell proliferation and invasion."
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"Next, biological function assays demonstrated that USP7 knockdown markedly inhibited OS cell migration and invasion, whereas USP7 overexpression enhanced it."
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