IndraLab

Statements

Inositol inhibits CASP1. 4 / 4
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reach
"Since it has been also documented that acute MI increased caspase-1 activity and formation of inflammasome [XREF_BIBR], decreased miR-1 during MI might be an unappreciated propyroptosis mechanism by which the synthesis of inflammasome components is enhanced contributing to the development of pyroptosis."
26491223
reach
"Here, a model integrates both biochemical and cellular data to provide a more quantitative estimation of MI inhibition of CA/SP1 cleavage, and thus formation of mature viruses in vivo."
27893830
reach
"To complete the data required to model MI inhibition of CA/SP1 cleavage (XREF_FIG) as a function of MI and Gag polymorph, specific binding affinities of BVM, BMS-1 and BMS-955176 toward VLPs containing Gag polymorphs were determined through the use of a competitive radioligand binding assay (XREF_TABLE)."
27893830
reach
"In seeking the mechanistic origins of this behavior we initially considered a simplified model for MI inhibition of CA/SP1 cleavage of viral particles in which cleavage only takes place in that fraction of particles not bound to the MI."
27893830