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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

NFkappaB decreases the amount of UCHL1. 3 / 3

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"It has been reported that NF-kappaB pathway transactivates BACE1 promoter and concomitantly down-regulates Uch-L1 expression."

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"Moreover, upon activation by tumor necrosis factor -alpha (TNF-alpha), NF-kappaB negatively regulates the transcription of the UCHL1 gene by binding to its response sequences within the promoter."

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"Expression of NF-kappaB suppressed UCH-L1 gene transcription."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

NFkappaB decreases the amount of UCHL1. 3 / 3

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