IndraLab

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USP4 activates DNA repair. 3 / 5
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"USP4 depletion also sensitized cells to ionizing radiation (IR) (XREF_FIG E; see XREF_SUPPLEMENTARY D for depletion of the NHEJ protein XRCC4), providing additional evidence that USP4 promotes DNA repair."
26455393
reach
"Next, we examined how USP4 promotes DNA repair using well established reporter assays for HR and NHEJ (Bennardo et al., 2008; Fattah et al., 2010; Moynahan et al., 2001)."
26387952
reach
"Here, we establish that the deubiquitylating enzyme USP4 promotes DNA-end resection and DNA repair by homologous recombination."
26455393