IndraLab

Statements

USP49 activates autophagy. 5 / 5
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"31 Inhibiting autophagy is still a traditional strategy to overcome CBP resistance in RB, 15 and our study demonstrates that USP49 modulates key autophagy‐related proteins to enhance autophagy, thereby promoting RB cell survival and conferring CBP resistance."
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"Furthermore, it was also revealed that IGF2BP3‐dependent m6A modification of USP49 enhances autophagy by stabilizing SIRT1 via its deubiquitination, helping RB cells survive under CBP treatment."
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"As autophagy activation is implicated in CBP resistance in RB, 15 we explored whether USP49 might promote CBP resistance in RB by inducing autophagy."
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"IGF2BP3-dependent N6-methyladenosine modification of USP49 promotes carboplatin resistance in retinoblastoma by enhancing autophagy via regulating the stabilization of SIRT1 ."
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"Our findings delineate a novel molecular network involving USP49-mediated autophagy in promoting CBP resistance in RB, offering potential targets for therapeutic intervention to enhance treatment efficacy and improve outcomes for RB patients."
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