IndraLab

Statements

USP9X activates Wnt. 9 / 10
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"In summary, these results indicate that USP9X stabilizes beta-catenin and activates Wnt and beta-catenin signal pathway to promote glioma cell proliferation and survival."
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"USP9X Promotes Canonical WNT Activation."
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"Taken together, these findings indicate that USP9X promotes canonical WNT activation, while WWP1 antagonizes canonical WNT activation."
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"For instance, recent data have indicated that USP9X promotes the activation of canonical Wnt signaling through deubiquitinating and stabilizing DVL2 in breast cancer cells [47]."
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"Among these DUBs, USP9X was also reported to promote Wnt signaling."
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"By evaluating signaling in U251 cells treated with a Wnt ligand, we found that USP9X knockdown partly blocked the activation of Wnt and beta- catenin pathway by regulating the stability of beta-catenin."
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"Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors."
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"These results indicate that USP9X can function to promote canonical WNT-driven proliferation while simultaneously guarding against migration and metastasis mediated by the WNT-PCP pathway."
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"USP9X enhances Wnt signaling through deubiquitinating Dv12 ."
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