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Statements

NAC inhibits MAPK8. 8 / 8
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"NAC abolished the upregulation of p-ERK and p-JNK, key proteins in the MAPK pathway, thereby inhibiting the MAPK-signaling pathway [23]."
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"Notably, NAC decreased RSL3 + JB-induced cell death ( Fig. 7 F), the proportion of apoptotic cells ( Fig. 7 B), MDA enhancement ( Fig. 7 G), and upregulation of c-PARP, c-cas-3, CHOP, p-JNK, p-p38, an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, NAC significantly attenuated MCLR triggered testicular eIF2s1 and MAPK8 activation, indicating that NAC counteracts MCLR induced unfolded protein response (UPR) in testes."
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"Free radical scavengers N -acetyl cysteine (NAC) and glutathione (GSH) inhibited ERK2 activation and, to a much lesser extent, JNK1 activation by tBHQ ⧸ BHA, implicating the role of oxidative stress i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Notably, the MTT assay showed that treatment with NAC, SB203580, SP600125 and U1026 all attenuated the cell death induced by Rg5 ( Fig. 8 ), which indicated that Rg5 induced the ROS production and the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"NAC significantly reversed the decrease in p-ERK and p-STAT3, and the increase in p-p38, p-JNK, cle-caspase-3 and cle-PARP."
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"As shown in Fig. 6 C and D, NAC blocked compound 7d -mediated activation of P-p38, P-JNK and Bax in SGC-7901 cells which was consistent with ROS-MMP pathway."
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"Mechanistically, RES and NAC decreased p-JNK and p-p38, the two major mitogen-activated protein kinases, in HCC cells."
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