IndraLab

Statements

YOD1 binds NCOA4. 5 / 5
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"Notably, YOD1 can be pulled down only in NCOA4-WT and NCOA4 239–382, suggesting that YOD1 may bind with NCOA4 through 239–382 domain (Fig.  xref )."
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"Co-immunoprecipitation experiments demonstrated that YOD1 binds to NCOA4 in a time-dependent manner after LPS stimulation Fig.  xref ."
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"To validate the specific region of YOD1 that interacts with NCOA4, we generated three plasmids containing different segmental mutations of YOD1."
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"Mechanistically, we demonstrated that YOD1 directly binds to and deubiquitinates NCOA4 via K48-linked chains, subsequently enhancing NCOA4 expression."
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"As shown in Fig.  xref , Flag-YOD1 and HA-NCOA4 were transfected into HPAEpiC cells as indicated; YOD1 and NCOA4 directly bind to each other under LPS stimulation."
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