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Quercetin inhibits RELA. 15 / 24
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"Quercetin also inhibited the p38 and JNK signaling pathways and activated NF-κB p65 [213]."
| PMC
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"Quercetin (25 muM) and galangin (25 muM) markedly inhibited the LPS induced nuclear trans-location of NF-kappaB and p65 (XREF_FIG)."
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"Compared with the RE control group, esophageal mucosal injury was improved and the expressions of NF-kappaBp65 and IL-8 were significantly decreased in the RE group treated with omeprazole or quercetin (P < 0.05)."
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"It has also been reported that quercetin could attenuate arthritis by targeting the HMGB1/TLR4/p38/ERK1/2/NF-κB p65 pathway in mice [44]."
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"Subsequently, we found that the administration of quercetin reduces RV induced elevation of phospho-NF-κB p65, p-IκBα, and p-IKK during early hours (2–8hpi) of infection (Figure 4C)."
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"Similarly, in this study, quercetin inhibited the spleen tissue inflammation and NF-κB p65 signaling pathway of carp, suggesting that quercetin may affect the disorder of immune inflammatory response [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Besides, QUR can inhibit cardiac NF-κB p65 in the hearts of I/R hearts activating the peroxisome proliferator-activated receptor (PPAR) ( xref )."
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"Moreover, quercetin could downregulate TLR4, MyD88, and p65 NF-κB, the key proteins in the TLR4/MyD88/NF-κB pathway, which may be associated with its neuroprotective and anti-inflammatory effects."
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"Quercetin (179) significantly inhibits the activation of p65/nuclear factor-kappa B (NF-κB) and the extracellular signal-regulated kinase 1/2/mitogen-activated protein kinase (ERK1/2/MAPK) pathways, as well as the levels of caspase-9 and caspase-3 in the liver tissue of mice with DM [57]."
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"Quercetin also reduced TLR4 overexpression and NF-κB p65 overactivation caused by sustained hyperglycemia, reduced NLRP3 inflammasome overactivation, and upregulated pro-angiogenic factors as well as neurotropic factors, which are essential for the protection of retinal ganglion cells [157]."
36866156
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"The suppression of Nox4 and NF-kappaB p65 expressions by quercetin , lycopene , and M2 were abrogated by EX-527 ( Fig. 4A-C ) ."
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"Quercetin could inhibit the activation of TLR4 and NF-kappaB p65."
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"Quercetin decreased Rel-A and p65, without modifying upstream signalling."
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"Quercetin decreased Rel-A and p65, without modifying upstream signalling."
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"For example, quercetin has been shown to suppress M1 macrophage polarization by downregulating the activity of NF-κB p65 and IRF5, thereby reducing the expression of M1 macrophage markers such as iNOS and IL-12."
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