IndraLab

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D-threo-isocitric acid inhibits TRAF6. 2 / 2
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"Crucially, ICT promoted proteasomal degradation of TRAF6, the critical adaptor protein that transduces RANKL and RANK signaling, and the inhibitory effect of ICT on osteoclastogenesis was reversed by the proteasomal inhibitor MG 132."
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"A randomized, double-blind, placebo-controlled trial showed that ICT increased the bone anabolism marker such as bone specific alkaline phosphatase and suppressed TRAF6 protein in peripheral blood osteoclast-precursor monocytes in post-menopausal women [74]."
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