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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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UCHL3 decreases the amount of TDP1. 3 / 3

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"Depletion of UCHL3 was sufficient to reduce TDP1 expression in rhabdomyosarcoma cells to levels comparable to control cells (XREF_FIG D, top) and led to hypersensitivity to the TOP1 poison CPT (XREF_FIG D, bottom)."

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"UCHL3 decreases the ubiquitination level of TDP1 leading to the inhibition of TDP1 degradation."

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"Depletion of UCHL3 in rhabdomyosarcoma cells reduced TDP1 levels and sensitized cells to TOP1 poisons."

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UCHL3 decreases the amount of TDP1. 3 / 3

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