IndraLab

Statements

Astemizole activates KCNH1. 5 / 5
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"In addition, we found that astemizole induced subcellular accumulation of Eag1 channels."
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"Chemical blockers : Imipramine and astemizole have been shown to abolish Eag currents and inhibit the cell proliferation of tumour cells and are easily available in the market for use [XREF_BIBR, XREF_BIBR]."
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"Astemizole, a new promising antineoplastic drug, targets Eag1 by blocking ion currents."
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"In the same study using an HCC model induced by diethylnitrosamine (DEN) in mice, they found that astemizole inhibited tumour development and decreased Eag1 mRNA and protein levels[98]."
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"Although astemizole has diverse targets, exploration of the mRNA and protein expression levels of Eag1 in these cells has revealed that the inhibition of Eag1 channels mediated by astemizole in HCC may potentially be the mechanism that accounts for its anti-proliferative and pro-apoptotic effects (49,85)."
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