IndraLab

Statements

OTUB1 ubiquitinates CD274. 2 / 2
| 2
reach
"In reciprocal experiments, PKP3 overexpression significantly suppressed PD-L1 ubiquitination, which was completely reversed by OTUB1 silencing (Fig. 6I)."
34416901
reach
"Although PD-L1 has been reported to be ubiquitinated or deubiquitinated by CSN5, USP22, OTUB1, FBXO38, STUB1, SPOP or HRD1 [28], only OTUB1 silencing blocked the regulatory effect of PKP3 on PD-L1 expression (Fig. S6D-I, Fig. 6F-G)."
34416901