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APP inhibits KCNQ2. 1 / 1
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"It has also been reported that Kcnq2 gene is down-regulated by Abeta in the hippocampus [XREF_BIBR] and, in this conditions, M-type K current reduction would rapidly increase the excitability of hippocampal principal and GABAergic interneurons, impairing rhythmicity and synchronic activities [XREF_BIBR, XREF_BIBR]."