
IndraLab
Statements
reach
"After several point mutations in AmmTX3 and introduction of positive charged residues in Discrepin, it was finally demonstrated that a common " hot spot " composed of two basic residues (Arg 18 and Lys 19 near the end of the alpha-helix) conferred hERG blockade activity of alpha-KTx 15 peptides [XREF_BIBR]."