IndraLab

Statements

KCNMA1 activates pyraclofos. 12 / 12
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"[71] Hoshi T, Pantazis A, Olcese R. Transduction of voltage and Ca2+ signals by Slo1 BK channels."
31647368
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"SLO mediated Cardiomyocyte Dysfunction is Independent of Voltage gated Calcium Channels."
25243426
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"BKβ1 is a key factor in BK channel electrophysiology that increases the sensitivity of BKα to Ca and voltage and subtly activates the BK channel within the physiological levels of the membrane potentials and intracellular calcium ([Ca ]i) concentration [16–19]."
37948436
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"Failure of verapamil to attenuate the aberrant response to streptococcal exotoxins supports the notion that SLO induced contractile dysfunction occurs independently of voltage gated L-type Ca 2+ channel activity."
25243426
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"Expression of hslo mRNA in Xenopus oocytes produces robust voltage and Ca (2+)-activated K+ currents."
7993625
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"The identification of Slo1 gene KCNMA1 and the availability of cDNA of Slo1 for functional expression of BK channels in exogenous cells (Atkinson et al., 1991; Adelman et al., 1992; Butler et al., 1993) allowed the studies to distinguish the distinct Ca and voltage dependent activation mechanisms (Cui et al., 1997)."
34744799
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"SLO1 channels are activated by both increased membrane voltage and intracellular Ca 2+ levels [XREF_BIBR, XREF_BIBR], and SLO3 channels are highly sensitive to intracellular alkalinization [XREF_BIBR]."
33562049
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"In marked contrast, basal (high frequency) outer hair cells had abundant BK channel immunoreactivity and BK currents contributed significantly to both voltage gated and ACh evoked K + currents."
21079807
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"NO mediated MaxiK (Ca) channel activation produces relaxation of guinea pig aorta independently of voltage dependent L-type Ca (2+) channels."
11120377
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"Thus, taken together, results from Shaker and Slo1 support a view of the voltage sensor as a dynamic structure whose activation involves changes in the relative position and interaction of transmembrane segments."
16505150
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"Once activated, Src tyrosine kinase inhibits the MaxiK channels causing depolarization and opening of voltage-dependent Ca 2+ channels and nonselective cation channels to induce contractions ( Alioua [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25046838
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"The mechanisms of voltage and Ca 2+ -dependent BK channel activation have been described by an allosteric model xref , which has successfully accounted for the functional properties of BK channel activation, pharmacology xref , modulation by regulatory subunits xref and mutations xref , xref ."
36351900