IndraLab

Statements


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"Thus, taken together, results from Shaker and Slo1 support a view of the voltage sensor as a dynamic structure whose activation involves changes in the relative position and interaction of transmembrane segments."

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"The identification of Slo1 gene KCNMA1 and the availability of cDNA of Slo1 for functional expression of BK channels in exogenous cells (Atkinson et al., 1991; Adelman et al., 1992; Butler et al., 1993) allowed the studies to distinguish the distinct Ca and voltage dependent activation mechanisms (Cui et al., 1997)."

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"In marked contrast, basal (high frequency) outer hair cells had abundant BK channel immunoreactivity and BK currents contributed significantly to both voltage gated and ACh evoked K + currents."

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"Failure of verapamil to attenuate the aberrant response to streptococcal exotoxins supports the notion that SLO induced contractile dysfunction occurs independently of voltage gated L-type Ca 2+ channel activity."

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"SLO mediated Cardiomyocyte Dysfunction is Independent of Voltage gated Calcium Channels."

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"Expression of hslo mRNA in Xenopus oocytes produces robust voltage and Ca (2+)-activated K+ currents."

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"SLO1 channels are activated by both increased membrane voltage and intracellular Ca 2+ levels [XREF_BIBR, XREF_BIBR], and SLO3 channels are highly sensitive to intracellular alkalinization [XREF_BIBR]."

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"NO mediated MaxiK (Ca) channel activation produces relaxation of guinea pig aorta independently of voltage dependent L-type Ca (2+) channels."