IndraLab

Statements

USP8 activates CD274. 3 / 3
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"On the contrary, cytotoxic T lymphocytes (CTLs) play tumor-killing roles in the TME, and it is illustrated to be activated by an application of the USP8 inhibitor along with anti-PD-L1 agents because inhibition of USP8 could prevent PD-L1 from proteasome degradation (Yang et al., 2023)."
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"The results found that lncRNA SNHG12 downregulation led to reduced tumor volume and weight (P < 0.01, Fig. 9A, B) and Ki67 positive rate, and increased CD8 positive rate (P < 0.01, Fig. 9C), along with reduced levels of SNHG12, PD-L1, and USP8 (P < 0.01, Fig. 9D), elevated ubiquitination level of PD-L1 (P < 0.01, Fig. 9E), and decreased   positive rate PD-L1 and USP8 (P < 0.01, Fig. 9F)."
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"One salient example is USP8, which upregulates PD-L1 in PDAC via direct deubiquitination [21] but downregulates PD-L1 in CRC through counteracting TRAF6-mediated K63-linked polyubiquitination [22]."
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