IndraLab

Statements

2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile activates KCNH2. 3 / 3
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"Verapamil antagonized dofetilide block of HERG channels, which suggests that they may share a common binding site."
10325236
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"Targets (2007) 11 (3) 329 The hERG potassium channel as a therapeutic targetExceptions include the calcium channel antagonist verapamil, which blocks hERG at clinically relevant concentrations [129], as does the antihistamine clemastine [130] and the selective serotonin receptor inhibitor citalopram [131]; yet none of these are associated with a substantial clinical risk of QT prolongation, TdP or even AP duration lengthening [132]."
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"However loss of indicator brightness represents a weakness in this strategy as although the anticipated CTD shortening with nifedipine was seen, the opposite trend due to off-target hERG block by verapamil was missed even though this was detected in parallel patching studies."
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