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USP49 ubiquitinates H2AX. 4 / 4
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"Importantly, similar results were obtained with IR-irradiated cells ( Supplementary Fig. S2 ), suggesting that excess amount of USP49 antagonized DSB-induced 53BP1 foci formation by suppressing γH2AX [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"1) Over-expression of USP49 suppressed DSB-induced ubiquitylation of γH2AX in its catalytic activity dependent manner."
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"This could suggest that USP49 suppresses 53BP1 binding to chromatin by deubiquitylating γH2AX when cells were not challenged."
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"In addition, we found that USP49 negatively regulates DSB-induced γH2AX ubiquitylation ( Fig. 1 B)."
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