IndraLab

Statements

UCHL1 activates Wnt. 3 / 3
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"UCHL1 has also been proposed to activate Wnt signaling through deubiquitination and stabilization of beta-catenin [XREF_BIBR]."
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"This is likely related to the Wnt/β-catenin signaling associated with Lgr5 expression, which indicates cell division and differentiation capacity [26]; however, UCHL1 also upregulates the Wnt pathway via β-catenin stabilization and T-cell factor (TCF)-dependent transcription."
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"Aberrant expression of UCHL1 in pediatric high-grade gliomas may promote cell invasion, transformation, and self-renewal properties, at least in part, by modulating Wnt and Beta catenin activity."
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