IndraLab

Statements

USP22 activates Wnt. 3 / 3
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"In pancreatic cancer cell lines a different mechanism in USP22 was found to modulate the lacatenin/Wnt signaling and therefore increase the abundance of FoxM1, a transcription factor that normally represses the expression of p21 and p27."
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"By up- and downregulation of USP22 expression, we also proved that USP22 can activate the Wnt and beta-Catenin pathway, which in turn affected the proliferation and migration of HepG2 cells."
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"In addition, USP22 can also activate Wnt/beta-catenin signaling axis to promote stemness and chemoresistance [ 67 ] (see Fig. 2 )."
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