IndraLab

Statements

OTUD7B binds HNF4A. 6 / 6
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sparser
"OTUD7B directly interacts with HNF4α and regulates the stability of HNF4α protein through deubiquitination."
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sparser
"Molecular docking analysis indicated a potential interaction between OTUD7B and HNF4α, with a docking score of −258.68 and a confidence score of 0.8979 (Fig. xref A)."
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reach
"Molecular docking analysis indicated a potential interaction between OTUD7B and HNF4α, with a docking score of −258.68 and a confidence score of 0.8979 (Fig. 7A)."
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sparser
"We used TransDSI to assess whether HNF4α is a deubiquitination substrate of OTUD7B. The TransDSI score for the OTUD7B-HNF4α interaction was 0.7979, suggesting a high probability that HNF4α is a substrate of OTUD7B."
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sparser
"Mechanistically, OTUD7B interacts with HNF4α and deubiquitinates it at the K48 site, thereby stabilizing its expression."
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sparser
"CoIP further confirmed these findings, demonstrating that OTUD7B directly interacts with HNF4α (Fig. xref B)."
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