IndraLab

Statements

Sestd1 binds CALM1. 8 / 8
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"The results indicated that CAM release from all formulations best fit the first-order kinetics model, as evidenced by higher correlation coefficients: 0.9981 ± 0.025 for CAM gel, 0.9894 ± 0.011 for CAM-BE gel, 0.9782 ± 0.021 for CAM-ES gel, and 0.9922 ± 0.018 for CAM-SOL."
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"These values were significantly higher than those obtained from the zero-order model (0.5145 ± 0.014, 0.6242 ± 0.011, 0.5751 ± 0.024, and 0.4150 ± 0.10 for CAM gel, CAM-BE gel, CAM-ES gel, and CAM-SOL, respectively) and the Higuchi diffusion model (0.8081 ± 0.096, 0.8475 ± 0.017, 0.8203 ± 0.035, and 0.7240 ± 0.016, respectively)."
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"Every CAM hydrogel preparation had n values in the range of 0.5 and 1.0 with values of 0.9151 ± 0.022 for CAM gel, 0.8602 ± 0.021 for CAM-BE gel, 0.8481 ± 0.035 for CAM-ES gel, and 0.8674 ± 0.012 for CAM-SOL, suggesting non-Fickian (anomalous) spread."
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"According to xref , the results showed that after 36 h, the amount of CAM that penetrated the CAM-BE gel formulation was considerably (P<0.001) higher, at 154.37 ± 3.92 μg/cm 2 compared to 101.38 ± 2.79 μg/cm 2 , 136.02 ± 3.35 μg/cm 2 and 129.08 ± 5.10 μg/cm 2 obtained from CAM gel, CAM-ES gel and CAM-SOL."
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"The synergistic effect of ethanol and PG association may be responsible for the higher skin deposition of 17.77 ± 1.13 μg/cm 2 of CAM-BE gel compared to 7.560 ± 0.86 μg/cm 2 , 14.01 ± 0.58 μg/cm 2 , and 5.434 ± 1.19 μg/cm 2 of CAM gel, CAM-ES gel, and CAM-SOL, respectively."
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"The higher deposition showed that CAM-BE gel accumulated for a longer period of time in the skin, serving as a reservoir and permitting CAM to function for an extended period of time at the nearby tissue of the skin’s deep layers in between treatments. xref , xref When compared to both CAM gel and CAM-SOL, the ethosomes’ ethanol, phospholipid, and edge activator considerably enhanced CAM penetration and epidermal deposition, according to earlier experimental findings."
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"Related studies have shown that it is of quite interest to study the changes in lipid CH 2 in the stratum corneum, xref and the literature suggests that the position of the peaks in the spectra is due to the stretching vibrations of SC lipids, and the (-CH 2 ) asymmetric stretching vibration band of the treated skin in the PBS group appeared at 2926.31 cm −1 , which shifted to higher wave numbers after the CAM-SOL and CAM-ES, and CAM-BE treatment shifted to higher wave numbers (2927.56 cm −1 , 2929.49 cm −1 and 2940.60 cm −1 ), respectively."
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"The Area 2850 peak’s decline indicated that the sample had an impact on the stratum corneum that included lipid extraction. xref Additionally, the peak’s shift to a higher wavenumber suggested that the stratum corneum’s intercellular lipid problem had increased and the CH 2 symmetric (2850 cm −1 ) vibration band of the treated skin in the CAM-SOL group appeared at 2854.27 cm −1 , which shifted to higher wave numbers after the PBS and CAM-ES, and CAM-BE treatment shifted to higher wave numbers (2853.31 cm −1 , 2852.34 cm −1 , and 2850.85 cm −1 ), respectively."
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