IndraLab

Statements

Isoflurane inhibits HCN1. 3 / 3
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"XREF_BIBR, XREF_BIBR In addition, volatile anesthetics such as halothane, or the more commonly used isoflurane, are able to inhibit HCN1 channels."
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"Isoflurane has been shown to inhibit the activity of HCN1 subunit containing HCN channels and increased the cortical neuronal excitability (Chen et al., 2009)."
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"The isoflurane mediated inhibition of HCN1 containing channels was postulated to contribute to synaptically drive slow-wave oscillations in thalamocortical circuits which might be associated with hypnosis [XREF_BIBR, XREF_BIBR]."
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