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USP28 binds otilonium bromide. 6 / 6
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"Then, a series of biochemical and biophysical methods were applied to characterize the interaction between USP28 and Otilonium Bromide at both the molecular and the cellular level."
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"The K48-linked di-Ub hydrolysis experiment was repeated for three times, and the representative data was shown.Carr-Purcell-Meiboom-Gill (CPMG) and saturation transfer difference (STD) NMR experiments[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, two biophysical methods including one-dimensional NMR and thermal shift assay were used to verify the interaction between Otilonium Bromide and USP28."
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"Here in this research, after the confirmation of the interaction between Otilonium Bromide and USP28, the immunoprecipitation assay was applied to validate the involvement of USP28 in the ubiquitinati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"After the characterization of the interaction between USP28 and Otilonium Bromide, cellular experiments were conducted to explore the novel therapeutic potential of the drug and also the related under[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"According to the results derived from the cellular thermal shift assay and the cellular Ub-PA assay, Otilonium Bromide could bind to USP28 and inhibit its covalent linking with ubiquitin in cellular c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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