IndraLab

Statements

ADAM10 activates IL1R1. 27 / 27
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"While the majority of the work on IL-1 signaling in NPCs has focused on IL-1β, IL-1α also activates the IL-1R1 and direct effects on NPCs have been observed."
20833246
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"Nonetheless, as both IL-1α and IL-1β activate IL-1Rs, these studies support the concept that activation of IL-1Rs regulate the expression and activity of hippocampal SERTs."
34010713
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"IL-1R is activated by its ligands IL-1α and IL-1β [ xref ; xref ]."
22137885
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"IL-1α and high mobility group box 1 (HMGB1), which activate IL-1R1 and TLR4, respectively, were proposed to play a central role in the phenotype observed and the expression levels of both molecules were increased in IL-1R8-deficient mice."
27148268
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"The other speculation is that IL-33 induces IL-1α and IL-1β (data not shown), and then IL-1α and IL-1β in turn activate IL-1R to induce iNOS in macrophages xref ."
24586149
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"By contrast, IL-1R is activated by IL-1α and IL-1β, which are produced by host cells xref ."
21720387
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"Membrane-associated IL-1α can activate IL-1R1 on target cells, such as T-cells or endothelial cells, in a juxtacrine manner."
24183701
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"At the cell membrane, IL-1α can bind to and activate IL-1R1 on adjacent cells, or can be released in membrane-bound apoptotic bodies, leading to further local and systemic inflammation xref ."
35729334
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"Neutrophil recruitment to the peritoneum in this model critically depends on IL-1R activation by IL-1α, not IL-1β, and on downstream induction of the chemokine CXCL5, and not CXCL1 or CXCL2 ( xref )."
35801586
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"Membrane IL-1α activates the IL-1R1 on adjacent cells by a mechanism termed “juxtacrine”."
30995499
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"Because IL-1α was not detected on the surface of EVs, it is not clear how IL-1α activates IL-1R1."
34010648
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"We also show that P. aeruginosa activates NF-κB in macrophages through both the TIR-containing adaptor protein (TIRAP)/MyD88 dependent and the TRIF-dependent pathways, and that IL-1α and IL-1β activation of IL-1R1 is an important feedback pathway in the host response to P. aeruginosa."
20826748
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"Taken together, these data show that either IL-1α or IL-1β can activate IL-1R1 in P. aeruginosa keratitis and that IL-1R1 has an essential role in regulating the inflammatory response to P. aeruginosa in the cornea."
20826748
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"The TLRs recognise conserved molecules derived from bacteria, fungi and viruses and contribute towards the innate immune response whilst the IL-1Rs are activated by the pro-inflammatory cytokines, IL-1α, IL-1β, IL-18 and IL-33 [ xref ]."
20525168
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"IL-1R1 receptor activation by IL-1α and/or IL-1β induces an array of factors including IL-1, IL-6 (CXCL6), IL-8 (CXCL8), interferon (IFN) α, β, and γ, defensins, matrix metalloproteinases (MMPs), C-reactive protein, etc ( xref , xref , xref )."
31788049
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"Altogether, inflammatory cytokine IL-1α activates IL1R, where the signal is transduced by p38-MAPK, resulting in the activation of Piezo1 expression through TFs, ATF2/CREBP1 and HNF4."
35602590
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"Along these lines, work done by the Rock laboratory has recently shown that activation of the IL-1R1 by IL-1α is a key pathway required for neutrophil recruitment to injured cells in peripheral tissue[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19932745
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"In addition, IL-1α, which also activates IL-1R, could contribute to the inflammatory response in vivo ."
23702978
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"IL-1α is primed and ready in skin resident immune cells for rapid action and, unlike IL-1β which is only biologically active in its cleaved mature form xref – xref , IL-1α activates IL-1R1 in both its cleaved mature and precursor pro forms xref ."
38643253
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"Indeed, liver lysates containing IL-1α promote neutrophilic migration in matrigel. xref Moreover, in peritonitis, IL-1α is released from necrotic cells and subsequently activates IL-1R1 present at the surface of mesothelial cells."
27569562
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"Although both IL-1α and IL-1β activate IL-1R1, we initially focused on the role of IL-1β."
37060806
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"IL-1α on the plasma membrane activates IL-1R [ xref ] and triggers a signaling cascade that degrades IRAK1 and IkBα to allow nuclear transition of NF-κB [ xref , xref ]."
36980256
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"IL-1α and IL-1β are two major cytokines able to activate IL-1R, and both of them may be released by stressed cells."
24172847
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"IL-1R is activated by both IL-1α and IL-1β, which have unique and shared functions ( xref )."
38363547
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"IL-1R can be activated by IL-1α and IL-1β within the inflamed comedones of acne patients [ xref ]."
38731983
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"Following EGFR activation IL-1α is released and activates IL-1R on keratinocytes creating a second autocrine loop leading to the activation of NF-κB signaling that modifies expression of specific keratinocyte genes involved in tumor formation including increasing expression and release of CXC ligands such as CXCL1 ( xref )."
27330189
sparser
"IL-1α is primed and ready in skin resident immune cells for rapid action and, unlike IL-1β which is only biologically active in its cleaved mature form[ xref – xref ], IL-1α activates IL-1R1 in both its cleaved mature and precursor pro forms[ xref ]."
38585803