IndraLab
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"Among these proteins, ubiquitin‐specific peptidase 33 (USP33) removes K63‐linked ubiquitin chains, destabilizing Parkin and suppressing mitophagy [33], Conversely, USP8 is capable of removing the K6‐linked ubiquitination from Parkin, thus stabilizing the protein and promoting mitophagy [51], Thus, targeting distinct Parkin ubiquitination modifications yields different outcomes."