IndraLab

Statements

All-cis-5,8,11,14,17-icosapentaenoic acid inhibits NLRP3. 14 / 14
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"When EPA and DHA inhibit the activation of NLRP3 inflammasome, β-arrestin-2 as the downstream protein of GPR120, can inhibit the activation of inflammatory factors by binding to NLRP3 [23, 25]."
37582087
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"In vitro models including adipocytes and macrophage, EPA and/or DHA were shown to inhibit nuclear factor-κB and c-Jun N-terminal kinase pathways and the priming and activation of the NLRP3 inflammasome by metabolic and non-metabolic signals (palmitate, LPS, ATP) ."
39511203
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"EPA also inhibited NLRP3 and IL-1beta and IL-6 and STAT3 inflammatory pathways and up-regulated the Wnt and beta-catenin pathway."
33523066
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"For example, a recent study has shown that EPA and DHA inhibit the NLRP3 inflammasome in macrophages, independently from their enzymatic products."
29706960
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"We found that EPA suppressed activation of the NLRP3 inflammasome by LPS with or without oxaliplatin (Supplementary Fig. S11A)."
36255412
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"In fact, EPA inhibited the upregulation of NLRP3 induced by LPS."
36255412
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"Moreover, we tested whether EPA and DHA inhibit LDL-induced priming and/or activation of WAT NLRP3 inflammasome ex vivo (secondary hypothesis)."
39511203
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"EPA + DHA can abolish the NLRP3 inflammasome activation, inhibiting the subsequent activation of caspase-1 [XREF_BIBR]."
28335527
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"When extracellular inflammatory stimulation occurs, IκB is phosphorylated, NF-κB cleavage, and then NF-κB dimer is activated and transferred into the nucleus, and the expression of inflammatory genes are up-regulated.It is reported that GPR120 is involved in the inflammatory signaling pathway activated by long-chain fatty acids, while EPA and DHA inhibit the activation of NLRP3 inflammatory bodies by activating GPR120 [22–24]."
37582087
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"Further analysis demonstrated that EPA and DHA could significantly suppress the inflammation response of the gut and brain by regulating the NLRP3/ASC signal pathway."
38393047
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"In fact, EPA and DHA inhibited the NLRP3 inflammasome in macrophage cell lines as well as in primary human and murine macrophages [74,80]."
36615103
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"These data collectively suggested that EPA suppresses NLRP3 inflammasome through GPR40 and GPR120.Previous studies have reported that FAs can activate G protein-coupled receptor 40 (GPR40) and GPR120."
31830477
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"These data collectively suggested that EPA suppresses NLRP3 inflammasome through GPR40 and GPR120."
31830477
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"Docosahexaenoic acid and eicosapentaenoic acid seem to diminish activation of the NLRP3 inflammasome via the G protein coupled receptor 120 (Gpr120) [XREF_BIBR, XREF_BIBR]."
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