IndraLab

Statements

USP15 increases the amount of SMAD3. 2 / 2
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"Results:. The authors demonstrated that USP15 knockdown significantly inhibited the proliferation, migration, and invasion of hypertrophic scar-derived fibroblasts in vitro and down-regulated the expression of TbetaRI, Smad2, Smad3, alpha-SMA, COL1, and COL3; in addition, USP15 overexpression showed the opposite trends (p < 0.05)."
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"Quantitative real-time polymerase chain reaction and Western blot analysis indicated that USP15 knockdown significantly reduced the mRNA and protein expression levels of TβRI, Smad2, and Smad3 and the fibrosis markers α-SMA, COL1, and COL3; USP15 overexpression showed the opposite trends."
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