IndraLab

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E2 increases the amount of CACNA1G. 3 / 3
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"E2 replacement significantly suppressed the mRNA expression of Adra1b, Cart, Chrm1, Esr1, Kiss1, Pdyn, NKB (Tac2), and Tac3r and significantly augmented expression of Cacna1g, Esr2, Ghsr, Kcnmb1, Kiss1r, and Pgr."

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"In the current study, E2 (or treatment with E2B) increased channel expression of Cacna1g and Kcnmb1 in WT females only, a finding supported by previous studies, but not in KIKO or ERKO [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

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"Presently, we show that E2 augmented the excitability of Kiss1 ARH neurons by amplifying Cacna1g, Hcn1 and Hcn2 mRNA expression and T-type calcium and h-currents."