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KRAS activates USP2. 3 / 3
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"Overexpression of KRAS (Fig. 6D) could partially abrogate the USP2 knockout-induced cell growth inhibition (Fig. 6E and F)."
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"These data suggest that GA can induce the proteasomal degradation of KRAS, which in turn impairs the downstream signal transduction in MM cells.3.2 Identification of USP2 as a novel target of GA."
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"Building on the observations that GA decreases KRAS protein levels in MM cells and inhibits USP2 activity, we hypothesized that USP2 may regulate the stability of KRAS."
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